If I cast Challenge targeting my buffed creature and an enemy creature, and my opponent responds with a removal spell targeting my buffed creature, but I use Sett's ability to save my creature, will Challenge still resolve?

Ruling: Yes, Challenge will still resolve even after the creature is saved by Sett's ability.

Nuances:

• This interaction assumes the removal spell has Reaction speed
• The scenario may involve a Showdown context where Hidden Blade could be used