If Lee Sin already has a buff and is targeted with Spirits Refuge (which states it doesn't buff if the target already has a buff), does Spirits Refuge buff him since Lee Sin can have any number of buffs?

Ruling: Yes, Spirits Refuge will buff Lee Sin even if he already has a buff. The text on Spirits Refuge stating it doesn't buff units that already have a buff is reminder text (italicized in parenthesis), not rules text. Lee Sin's passive ability allows him to stack buffs, which overrides the general rule.

Nuances:

• Reminder text is italicized in parenthesis and serves only as a reminder of general rules, not as binding rules text
• The reminder text exists to remind players of the default rule that units can only have one buff, but units like Lee Sin circumvent that rule